Officers are growing increasingly concerned for the welfare of 50-year-old Gloris Smith of Nuthall, Nottingham.
Gloris was last seen at 2pm yesterday.
Officers believe she may be in the Worksop area.
She is described as black, about 5ft 4ins tall, of slim build, with black hair.
Anyone who has seen Gloris or knows her whereabouts is asked to call 101.